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(2016) Clin Cancer Res
PubMed Central PMCID: PMC5603554
injection[3]
The effect starts 5 minutes after the injection
Chemical Name: 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1
MAK-683 - CAS# 1951408-58-4 Catalog No.:M7137-2 (2016) Clin Cancer ResMAK 683, CAS No. 1951408 58 4, is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3 binding pocket and prevents the interaction of EED
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